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. Part of the book series (NSSA, volume 208) Abstract The blood vessels in and around tumors can be distinguished from normal vasculature in several ways. Tumor-associated vessels are derived from surrounding host blood vessels as a result of neovascularization ( Folkman, 1985) and are typically more permeable than normal vessels ( Dvorak et al., 1988, Gerlowski and Jain,1983).

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These observations lead to the hypothesis that tumors can alter blood vessel function by producing regulator substances. A polypeptide regulator known as vascular permeability factor (VPF) or vascular endothelial growth factor (VEGF) has now been purified and found to display a surprisingly wide spectrum of vascular activities, some of which are pro-inflammatory in nature.

In addition to synthesis by tumor cells, VPF has now been found to be a product of monocytes and lymphocytes. Taken together, these results suggest that VPF may be a new inflammatory cytokine.

This entry was posted on 07.10.2019.